Advanced Transungual Drug Delivery Systems

Objectives to cover:

• Introduction: Provides an overview of onychomycosis and emphasizes the need for improved transungual drug delivery systems.
• Nail Barrier and Drug Penetration: Explains the structure of the nail and the challenges associated with drug permeation through the nail plate.
• Conventional Transungual Formulations: Discusses existing topical and oral antifungal therapies along with their limitations.
• Advanced Drug Delivery Systems: Reviews microspheres, nanoparticles, and other novel delivery systems for enhanced antifungal therapy.
• Microspheres-in-Gel Systems: Describes the mechanism, advantages, and applications of microsphere-loaded gel formulations for transungual delivery.
• Polymers and Formulation Methods: Highlights the role of polymers such as ethyl cellulose and PLGA and the O/W emulsion solvent evaporation technique.
• Evaluation Techniques: Summarizes methods used to assess drug release, nail permeation, and antifungal activity of formulations.
• Research Gaps and Future Scope: Identifies current challenges in transungual drug delivery and explores future research opportunities.
• Conclusion: Summarizes the key findings and outlines the future outlook for effective microsphere-based transungual drug delivery systems.

Reference:  APA style