Severe Dengue Presenting with Acute Hepatic Failure

Introduction: Overview of severe dengue as a systemic viral illness with potential multi-organ involvement.

Epidemiology: Incidence of severe dengue and frequency of hepatic complications in endemic regions.

Pathophysiology: Mechanisms of liver injury including viral cytotoxicity, immune response, and hypoperfusion.

Clinical Presentation: Symptoms such as high fever, jaundice, abdominal pain, and bleeding manifestations.

Diagnostic Evaluation: Role of liver function tests, coagulation profile, serology, and imaging.

Management Strategies: Supportive care, fluid management, monitoring for encephalopathy, and ICU support.

Complications: Risks of coagulopathy, hepatic encephalopathy, shock, and multi-organ failure.

Prognosis: Factors influencing outcomes including early recognition and severity of liver dysfunction.

Conclusion: Importance of timely diagnosis and multidisciplinary care to reduce mortality in severe dengue with hepatic failure.