Hypertriglyceridemia-Related Acute Pancreatitis
Word Count : 3000
Objectives to cover:
Introduction: Overview of acute pancreatitis precipitated by markedly elevated triglyceride levels.
Epidemiology: Accounts for a small but significant proportion of pancreatitis cases, especially in metabolic syndrome.
Risk Factors: Includes uncontrolled diabetes, obesity, alcohol use, and genetic lipid disorders.
Pathophysiology: Excess triglycerides break down into toxic free fatty acids causing pancreatic inflammation.
Clinical Presentation: Severe epigastric pain, nausea, vomiting, and elevated pancreatic enzymes.
Diagnostic Evaluation: Serum triglycerides >1000 mg/dL with supportive imaging findings confirm suspicion.
Management: Initial treatment involves fluid resuscitation, insulin therapy, and triglyceride reduction.
Complications: May lead to necrosis, organ failure, or recurrent pancreatitis if untreated.
Conclusion: Early recognition and rapid lipid control are key to improving outcomes and preventing recurrence.