NSAID & Antiepileptic Skin Reactions

Objectives to Cover

• Introduction – Understand cutaneous adverse drug reactions (CADRs) and their importance in clinical practice.
• NSAIDs & Antiepileptics – Explore the common uses of NSAIDs and antiepileptic medications and their potential to cause skin reactions.
• Cutaneous Drug Reactions – Understand the different types and clinical presentations of drug-related skin reactions.
• Common Symptoms – Examine manifestations such as rash, itching, urticaria, erythema, swelling, and skin peeling.
• Severe Reactions – Review serious conditions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
• Drug-Related Patterns – Identify commonly implicated NSAIDs and antiepileptic drugs and assess patterns of adverse reactions.
• Risk Factors – Examine factors such as age, sex, previous drug reactions, comorbidities, and concurrent medications.
• Clinical Assessment – Review the importance of medication history, physical examination, and relevant investigations in diagnosis.
• Severity Assessment – Evaluate the severity, onset, duration, and clinical outcomes of reported skin reactions.
• Management – Understand drug withdrawal, supportive treatment, symptomatic management, and specialist referral when required.
• Patient Outcomes – Assess recovery, complications, hospitalization, and other documented outcomes following adverse reactions.
• Retrospective Analysis – Review medical records to evaluate the frequency, characteristics, suspected drugs, and outcomes of cutaneous reactions.
• Prevention – Explore strategies for early recognition, appropriate prescribing, documentation of drug allergies, and patient counselling.
• Conclusion – Summarise the patterns and clinical significance of NSAID- and antiepileptic-associated skin reactions and the importance of timely recognition and management.

Reference: IEEE.

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